O Brother, Where Art Thou? (2000)

Disenchanted with the daily drudge of crushing rocks on a prison farm in Mississippi, the dapper, silver-tongued Ulysses Everett McGill (George Clooney) busts loose. Except he's still shackled to his own chain-mates from the chain gang -- bad-tempered Pete (John Turturro), and sweet, dimwitted Delmar (Tim Blake Nelson). With nothing to lose and buried loot to regain -- before it's lost forever in a flood -- the three embark on the adventure of a lifetime in this hilarious offbeat road picture. Populated with strange characters, including a blind prophet, sexy sirens, and a one-eyed Bible salesman (John Goodman), it's an odyssey filled with chases, close calls, near misses, and betrayal that will leave you laughing at every outrageous and surprising twist and turn.